International journal of therapeutic innovation
International Journal of Therapeutic Innovation, a journal of scientific research, publishes Original Research Articles, Review Articles, Short Communications, Case Studies, Clinical Images, Perspectives, Systematic reviews, Meta-analyses, Short communications, Research letters, Letters to the editor, and other articles of interest to medical, Pharmaceutical, and basic science professionals. As it relates to topics concerning the medical and pharmaceutical fields, the journal maintains an international scope and is considered the elite journal in the field of medicine and pharmaceuticals.
Artificial comprehensive review on design, synthesis, and pharmacological evaluation of chromone-based derivatives as antimicrobial and anti-inflammatory agents
Chromone (4H-chromen-4-one) represents a privileged heterocyclic scaffold widely distributed in nature and synthetic compounds, exhibiting diverse pharmacological activities including antimicrobial, anti-inflammatory, anticancer, antiviral, and antioxidant properties. The structural versatility of chromone nucleus allows strategic modifications at various positions to develop novel therapeutic agents. This comprehensive review consolidates recent advances in the design, synthesis, and biological evaluation of chromone-based derivatives, with particular emphasis on sulfonamide-chromone conjugates, 2-aminochromone bis-triazole hybrids, and 3-substituted chromones. The synthetic methodologies discussed include Vilsmeier-Haack formylation, Baker-Venkataraman rearrangement, Claisen rearrangement, and copper(I)-catalyzed azide-alkyne cycloaddition (click chemistry). Structure-activity relationship studies reveal that substitution patterns significantly influence antimicrobial and anti-inflammatory potency. This review aims to guide medicinal chemists in rational design and development of chromone-based therapeutics.
Chromone, sulfonamide, 1,2,3-triazole, antibacterial activity, anti-inflammatory, click chemistry, Vilsmeier-Haack reaction.
Copyright (c) 2026 International journal of therapeutic innovation
Artificial intelligence (AI) in hospital pharmacy: a comprehensive review
This review examines the evolving role of artificial intelligence (AI) in clinical and hospital pharmacy services. A comprehensive literature search across PubMed, Scopus, Web of Science, Embase, and Google Scholar, covering studies up to July 2025, identified research using keywords such as artificial intelligence, machine learning, clinical pharmacy, hospital pharmacy, medication management, and decision support systems. Selected studies discussing AI applications, benefits, challenges, and outcomes were analysed through narrative synthesis. Findings show that AI strengthens pharmacy operations by improving inventory accuracy, reducing medication errors, enhancing dispensing safety, and streamlining drug distribution. Machine learning and decision support tools support therapy selection, predict medication demand, detect drug–drug interactions, and promote personalised care. AI adoption also improves workflow efficiency, reduces administrative tasks, and enhances pharmacist training. Originally developed for complex computational tasks, AI now transforms healthcare through digital record keeping, automation, and diagnostic tools. Its growing use in drug discovery, formulation development, and hospital pharmacy highlights its expanding impact on professional pharmacy practice.
Artificial intelligence (AI), Machine learning, Clinical pharmacy, Hospital pharmacy, Medication management, Decision support systems, Inventory management, Medication errors, Drug–drug interactions, Personalised care, Pharmacy automation, Pharmacist training, Drug distribution, Digital health, Diagnostic technologies, Drug discovery, Formulation development.
Applications of Oxygen-enhancing plants used in the house to enhance the oxygen-rich environments for combating pollution challenges
In modern day’s urban cities areas are facing air pollutions. It has been seen that urban cities areas situated homes environment having also polluted air present age much high. The bad air quality of indoor home increases the air related diseases in persons such as asthma, sneezing, headache, heart related problems etc. The problems of indoor house air quality can manage by using oxygen rich indoor plants and cottons. It has been seen that the possibilities of oxygen-enhancing these indoor plants are buildup sustainable environment and reduce indoor air pollution and get better human health. In this review articles covered the name of oxygen richest plants, advantages and their applications.
Oxygen-Enhancing Indoor Plants, Roles of reactive oxygen species, antioxidant enzymes, health, air quality assessment, biochemical oxygen demand.
Waste-derived nutritional seed balls coated with mycorrhizal inoculum: a one health perspective
The fast-paced agriculture development has increased risks to human and environmental health due to over use of hemical fertilizers and pesticides. We are at the verge of finding sustainable solution to this problem. Nutritional seed balls constructed from oil seed meals and waste-derived binders, and coated with Arbuscular Mycorrhizal Fungi (AMF) and Ectomycorrhiza (ECM), present a promising solution. A nutrient-rich carriers and biodegradable binders ensure stability and environmental compatibility. The fungal inoculation of both AMF and ECM enhances plant nutrient uptake, stress tolerance, and root health that reduces fertilizer dependency. The vital role of this system is in its alignment with the One Health paradigm by supporting human, animal, plant, and environmental well-being. T hese seed ball will not only be useful in agriculture but also in nurseries, agroforestry, and reforestation programs that shows that they are versatile and has great potential for large-scale application. This review synthesizes current evidence on their agronomic benefits, waste valorization potential, and role in advancing sustainable agriculture and food security.
Caesalpinia bonduc, Soxhlet extraction, Ethyl acetate, MTT assay, Anticancer activity, MCF-7 cells, Breast cancer, Bioactive compounds, Cytotoxicity, Natural products, Traditional medicine, Plant-based therapies, Cell viability, Cancer treatment.
Factors associated with treatment outcomes in hospitalized patients withprimary hypertension: a retrospective cross-sectional study in Vietnam
Hypertension is a major public health problem and a leading contributor to cardiovascular morbidity and mortality, yet blood pressure control remains suboptimal in many clinical settings, particularly among hospitalized patients with complex clinical profiles. This retrospective cross-sectional study aimed to identify patient-related and treatment-related factors associated with treatment outcomes in hospitalized patients with primary hypertension. The study was conducted at the Department of Cardiology, Can Tho Central General Hospital, Vietnam, from January to June 2024, and included 378 inpatient medical records of patients diagnosed with primary hypertension. Treatment outcome was defined as achievement of target blood pressure at discharge according to the 2022 Vietnam National Heart Association guidelines. Demographic characteristics, clinical variables, comorbidities, renal function, body mass index, antihypertensive treatment regimens, and clinically significant drug-drug interactions were analyzed. At discharge, 97.1% of patients achieved target blood pressure, with mean systolic blood pressure decreasing from 171.4 ± 15.9 mmHg to 124.1 ± 16.4 mmHg and mean diastolic blood pressure decreasing from 91.5 ± 11.6 mmHg to 81.9 ± 12.9 mmHg. Failure to achieve target blood pressure was significantly associated with older age, higher hypertension stage, elevated serum creatinine, overweight or obesity, inappropriate antihypertensive prescribing, suboptimal treatment regimens, and clinically significant drug-drug interactions. These findings demonstrate the multifactorial nature of blood pressure control in hospitalized patients and provide evidence to support targeted strategies for improving treatment outcomes in inpatient hypertension management.
Assessment of anticancer potential in Caesalpinia Bondoc: a comparison between leaf and kernel extracts
This study presents a comparative evaluation of the anticancer activity of leaf and seed extracts of Caesalpinia bonduc. Ethyl acetate extracts were prepared using the Soxhlet extraction technique to isolate the plant’s bioactive constituents. C. bonduc was selected due to its long history in traditional medicine and its reported pharmacological potential. The cytotoxic effects of the extracts were assessed against MCF-7 breast cancer cells, a widely used cell line in breast cancer research.The experimental results indicate that both leaf and seed extracts possess notable anticancer properties, demonstrated by their ability to reduce cell viability and inhibit the proliferation of MCF-7 cells. These findings suggest that C. bonduc contains potent bioactive compounds capable of inducing growth inhibition or cell death in cancer cells. Further investigation into the specific phytochemicals responsible for these effects and their underlying mechanisms may support the development of novel plant-based anticancer agents. Overall, this study adds to the growing body of evidence supporting the value of medicinal plants in cancer research and highlights the significance of traditional knowledge in guiding modern therapeutic discoveries.
Formulation and evaluation of herbal syrup for its anti-obesity properties
<!-- [if gte vml 1]><o:wrapblock><v:shape id="Graphic_x0020_11" o:spid="_x0000_s1026" style='position:absolute;left:0;text-align:left;margin-left:34.55pt; margin-top:47.7pt;width:526.3pt;height:.5pt;z-index:-15727616;visibility:visible; mso-wrap-style:square;mso-wrap-distance-left:0;mso-wrap-distance-top:0; mso-wrap-distance-right:0;mso-wrap-distance-bottom:0; mso-position-horizontal:absolute;mso-position-horizontal-relative:page; mso-position-vertical:absolute;mso-position-vertical-relative:text; v-text-anchor:top' coordsize="6684009,6350" o:gfxdata="[binary] " path="m6684009,l,,,6096r6684009,l6684009,xe" fillcolor="black" stroked="f"> <v:path arrowok="t"/> <w:wrap type="topAndBottom" anchorx="page"/> </v:shape><![endif]--> Herbal medicine, which uses fruit extract for therapeutic purposes, is where the majority of herbal syrups originated. In addition to alternative dosages from herbal medications, syrup formulations are also available. Nowadays, syrup is used to treat a wide range of conditions and alleviate sickness symptoms.
AI chatbots, mental health, emotional intelligence, depression, anxiety, human-AI interaction, ethical implications.
Copyright (c) 2025 International journal of therapeutic innovation
A review on Pharmacovigilance and drug safety post-marketing surveillance
<!-- [if gte vml 1]><o:wrapblock><v:shape id="Graphic_x0020_9" o:spid="_x0000_s1026" style='position:absolute;left:0;text-align:left;margin-left:34.55pt; margin-top:94.45pt;width:526.2pt;height:.5pt;z-index:-15728128;visibility:visible; mso-wrap-style:square;mso-wrap-distance-left:0;mso-wrap-distance-top:0; mso-wrap-distance-right:0;mso-wrap-distance-bottom:0; mso-position-horizontal:absolute;mso-position-horizontal-relative:page; mso-position-vertical:absolute;mso-position-vertical-relative:text; v-text-anchor:top' coordsize="6682740,6350" o:gfxdata="[binary] " path="m6682740,l,,,5851r6682740,l6682740,xe" fillcolor="black" stroked="f"> <v:path arrowok="t"/> <w:wrap type="topAndBottom" anchorx="page"/> </v:shape><![endif]--> Drug students play an important role in ensuring drug safety by monitoring unwanted drug reactions (ADRs) and other drug problems once drugs enter the market. This review examines the importance of subsequent market surveillance (PMS) for the identification, evaluation and prevention of side effects that may not be recognized by side effects. Various pharmacy systems, regulatory framework conditions, and reporting mechanisms used around the world are being discussed, highlighting their impact on public health and drug safety. Issues related to reporting, data management and regulatory harmonization can also be examined. This check concludes with recommendations to improve drug students' practices to improve patient safety and optimize the effectiveness of the drug in a real environment.
Pharmacovigilance, Drug Safety, Post-Marketing Surveillance, Adverse Drug Reactions (ADRs), Risk Management, Regulatory Frameworks, Drug Monitoring, Public Health, Spontaneous Reporting, Signal Detection.
Impact on mental health problems during coxsackievirus outbreak in the general public: Narrative review
<!-- [if gte vml 1]><o:wrapblock><v:shape id="Graphic_x0020_8" o:spid="_x0000_s1026" style='position:absolute;left:0;text-align:left;margin-left:34.55pt; margin-top:140.85pt;width:526.3pt;height:.5pt;z-index:-15727104;visibility:visible; mso-wrap-style:square;mso-wrap-distance-left:0;mso-wrap-distance-top:0; mso-wrap-distance-right:0;mso-wrap-distance-bottom:0; mso-position-horizontal:absolute;mso-position-horizontal-relative:page; mso-position-vertical:absolute;mso-position-vertical-relative:text; v-text-anchor:top' coordsize="6684009,6350" o:gfxdata="[binary] " path="m6684009,l,,,6096r6684009,l6684009,xe" fillcolor="black" stroked="f"> <v:path arrowok="t"/> <w:wrap type="topAndBottom" anchorx="page"/> </v:shape><![endif]--> Coxsackievirus group B (CVB), a member of the Picornaviridae family and enterovirus genus, poses risks during pregnancy due to its potential to cause severe fetal and neonatal infections. Transmission primarily occurs through fecal–oral routes, with infections peaking mostly in warmer months. Vertical transmission to the fetus can lead to conditions such as myocarditis, encephalitis, and systemic neonatal disease, presenting clinically as severe myocardial syndromes and neurological deficits. Diagnostic challenges include detecting asymptomatic maternal infections and conducting in utero assessments using advanced techniques like RT-PCR from amniotic fluid samples should be encouraged. Morbidity and mortality associated with congenital CVB infections are notable. Current treatments are limited to supportive care, with emerging therapies showing promise but requiring further study for efficacy. Mental health impact due to this virus results in speech development failure and autistic feature. Future research should aim to fill knowledge gaps in epidemiology, improve diagnostic capabilities, and develop targeted interventions to enhance maternal and fetal outcomes and other health issues due to this virus.
Enterovirus, Neonatal illness, Neurological deficits, mental health.
Beyond the wrist: A holistic wearable for women’s well-being
Women frequently face significant mental health challenges, including stress, anxiety, and depression, particularly during hormonal changes and pregnancy. Many current solutions are not able to provide the personalized and timely care needed to effectively manage these issues. This paper explores a wearable device that offers a tailored approach to managing mental health by tracking key physical and emotional indicators. The study aimed to assess whether this device could provide timely support for mental health challenges associated with hormonal fluctuations. The device uses basic sensors to track heart rate, stress levels, and sleep patterns. Based on these measurements, it helps users make adjustments to improve their well-being over time. Key features of the device include hormone tracking, monitoring emotional states, and suggesting lifestyle changes. The results showed that the device helped improve mood and reduce stress. By observing when users were likely to feel stressed or low, it offered helpful interventions to better manage those emotions. <!-- [if gte vml 1]></o:wrapblock><![endif]-->In addition, the device encourages mindfulness, relaxation exercises, and strategies for better sleep, giving users practical tools to improve their overall mental well-being. This wearable represents a significant advancement in supporting women’s mental health, specifically by helping them manage hormonal changes and related mental health challenges.
Women’s mental health, Wearable technology, Artificial intelligence (AI), Hormonal fluctuations, Stress management, Anxiety and depression, Postpartum health, Personalized health support, Predictive insights, Adaptive hormone tracking.
Recent research and uses of asparagus racemosus (Shatavari)
Asparagus racemosus, commonly known as Shatavari, is a well-established herb in Ayurvedic medicine, renowned for its therapeutic properties that have been utilized for centuries. This article explores the recent research on Shatavari, highlighting new trends and emerging uses in modern medicine. Recent pharmacological studies have shed light on the plant's potent anti- inflammatory, antioxidant, and immunomodulatory properties, revealing its potential in managing various health conditions, including arthritis, autoimmune disorders, and gastrointestinal ailments. One of the most well-known applications of Shatavari is its beneficial effects on women's health, particularly in managing hormonal imbalances, promoting lactation, and enhancing fertility
Asparagus racemosus, Shatavari, Immunomodulator, Antioxidant, Anti-Ageing, Herbal Formulations, Adaptogenic.
Md Ahatesham Irakee, Somesh Kumar Saxena*, Shailesh Jain
The role of AI Chatbots in providing mental health support: emotional perception, human-AI interaction, and ethical implications
<!-- [if gte vml 1]><o:wrapblock><v:shape id="Graphic_x0020_11" o:spid="_x0000_s1026" style='position:absolute;left:0; text-align:left;margin-left:34.55pt;margin-top:187.6pt;width:526.2pt; height:.6pt;z-index:-15727616;visibility:visible;mso-wrap-style:square; mso-wrap-distance-left:0;mso-wrap-distance-top:0;mso-wrap-distance-right:0; mso-wrap-distance-bottom:0;mso-position-horizontal:absolute; mso-position-horizontal-relative:page;mso-position-vertical:absolute; mso-position-vertical-relative:text;v-text-anchor:top' coordsize="6682740,7620" o:gfxdata="[binary] " path="m6682740,l,,,7314r6682740,l6682740,xe" fillcolor="black" stroked="f"> <v:path arrowok="t"/> <w:wrap type="topAndBottom" anchorx="page"/> </v:shape><![endif]--> <!-- [if gte vml 1]></o:wrapblock><![endif]--> This study investigates the role of AI chatbots in providing mental health support, focusing on emotional perception, human-AI interaction, and ethical implications. The research aimed to evaluate the effectiveness of AI chatbots in reducing symptoms of depression and anxiety, enhance emotional intelligence, and explore ethical concerns related to data security and emotional dependency. A mixed-methods approach was employed, combining quantitative measures (PHQ-9 for depression, GAD-7 for anxiety, and emotional intelligence assessments) with qualitative data from participant interviews. Results show a significant reduction in depression and anxiety symptoms after a 4-week AI chatbot intervention (p < 0.05), with large effect sizes (Cohen's d = 0.75 and 0.72 for depression and anxiety, respectively). Additionally, participants demonstrated notable improvements in emotional intelligence, particularly in self-awareness, emotional regulation, and empathy. The qualitative data revealed positive perceptions of AI's emotional support capabilities, though concerns about emotional dependency on chatbots and data privacy were prevalent. These findings suggest that AI chatbots can be effective tools in mental health interventions, but ethical issues must be addressed to ensure safe and beneficial use. The study emphasizes the potential of AI chatbots in enhancing emotional regulation and decision- making, while also highlighting the importance of considering ethical implications for widespread adoption. Future research should focus on refining chatbot capabilities and addressing privacy concerns to enhance user trust and long-term engagement.
Artificial intelligence in drug delivery
<!-- [if gte vml 1]><o:wrapblock><v:shape id="Graphic_x0020_9" o:spid="_x0000_s1026" style='position:absolute;left:0;text-align:left; margin-left:34.55pt;margin-top:78.8pt;width:526.3pt;height:.5pt;z-index:-15727616; visibility:visible;mso-wrap-style:square;mso-wrap-distance-left:0; mso-wrap-distance-top:0;mso-wrap-distance-right:0;mso-wrap-distance-bottom:0; mso-position-horizontal:absolute;mso-position-horizontal-relative:page; mso-position-vertical:absolute;mso-position-vertical-relative:text; v-text-anchor:top' coordsize="6684009,6350" o:gfxdata="[binary] " path="m6684009,l,,,6096r6684009,l6684009,xe" fillcolor="black" stroked="f"> <v:path arrowok="t"/> <w:wrap type="topAndBottom" anchorx="page"/> </v:shape><![endif]--> Artificial intelligence (AI) tools are improving the drug delivery process from drug formulation to stimulating, Programming and optimising drug delivery in patients. Artificial intelligence (AI) it is the emerged powerful tool to minimise patient compliance. Healthcare, including drug delivery. It is the transformation of the pharmaceutical product to improve patient care. In that, improved patient adherence. This review provides the various AI-dependent approaches in pharmaceutical technology, tools, highlighting their benefits, and recent trends in AI in novel drug delivery systems.
Artificial Intelligence (AI), Machine Learning (ML), Deep Learning, Drug Discovery, Personalised Medicine.
<!-- [if gte vml 1]><o:wrapblock><v:shape id="Graphic_x0020_11" o:spid="_x0000_s1026" style='position:absolute;left:0; text-align:left;margin-left:34.55pt;margin-top:109.95pt;width:526.2pt; height:.45pt;z-index:-15727616;visibility:visible;mso-wrap-style:square; mso-wrap-distance-left:0;mso-wrap-distance-top:0;mso-wrap-distance-right:0; mso-wrap-distance-bottom:0;mso-position-horizontal:absolute; mso-position-horizontal-relative:page;mso-position-vertical:absolute; mso-position-vertical-relative:text;v-text-anchor:top' coordsize="6682740,5715" o:gfxdata="[binary] " path="m6682740,l,,,5617r6682740,l6682740,xe" fillcolor="black" stroked="f"> <v:path arrowok="t"/> <w:wrap type="topAndBottom" anchorx="page"/> </v:shape><![endif]--> Quantitative structure–activity relationship models (QSAR models) are regression or classification models used in the chemical and biological sciences and engineering. Like other regression models, QSAR regression models relate a set of "predictor" variables (X) to the potency of the response variable(Y), while classification QSAR models relate the predictor variables to a categorical value of the response variable. In QSAR modeling, the predictors consist of physico-chemical properties or theoretical molecular descriptors of chemicals; the QSAR response- variable could be a biological activity of the chemicals. QSAR models first summarize a supposed relationship between chemical structures and biological activity in a data-set of chemicals. Second QSAR models predict the activities of new chemicals. Related terms include quantitative structure–property relationships (QSPR) when a physico-chemical property or reactivity is modeled as response variable.
QSAR, Docking, QSPR, Drug Design, Molecular Descriptor, Biological activity.
Use of quality control parameters in the evaluation of crude drugs
The increasing use of herbal medicines in healthcare worldwide has made it imperative to establish robust quality control (QC) systems for crude drugs. Crude drugs are plant materials or their derivatives that have therapeutic properties. These drugs, derived from plant, animal, or mineral sources, are typically used in traditional medicine and pharmaceutical formulations. However, the complexity of their biological activities, variations in composition due to geographical and seasonal factors, and potential adulteration make them difficult to standardize. Therefore, stringent quality control parameters are required to ensure their safety, efficacy, and consistency. Quality control in herbal medicine focuses on various factors such as identification, purity, content of active ingredients, and microbiological safety.
Quality Control, Herbal Medicines, Crude Drugs, Standardization, Adulteration.
Malaria: A Comprehensive Review of the Disease Life Cycle, Symptoms, Types, Treatment, and Herbal Remedies
Malarial is still the very important parasitic disease in the world. Traditional medicines are used to treat malaria on thousands of years and the sources of artemisinin and quinine derivatives with the high levels of drug resistance, the more cost of artemisinin based on combination therapies and spurious antimalarial drugs, traditional medicine is important and sustainable source of malaria is treatment of endemic areas. The discovery and use of natural compounds required for investigation of safety and efficacy previous to release into the market. <!-- [if gte vml 1]></o:wrapblock><![endif]-->By referring to some recent literatures, data were collected about plant used for the treatment of malaria, evaluation of plant extracts for anti-malarial activity, modes of the action of natural antimalarial agents, and recent research on antimalarial plants in Iran and other countries.
Malaria, Antimalarial, Natural Products, Plasmodium, Medicinal Plants, Traditional Medicine.
Phytochemical screening and antimicrobial activity of leaf, stem, root and their callus extracts in Rauwolfia Serpentina
Phytochemical screening and Antimicrobial studies were carried out in a medicinally important plant species, Rauwolfia Serpentina. The aim of the present study was to screen leaf, stem and root extracts and their callus (NaCl stressed & unstressed) extracts of R. serpentina(24 months old) for the qualitative analysis of phytochemicals like alkaloids, flavonoids, saponins, tannins and gums and Mucilages and to study antibacterial and antifungal activities in these extracts. Phytochemical screening revealed that Alkaloids are major phytochemicals in leaf, stem and root extracts of R. serpentina (24 months old). In antimicrobial activity studies, maximum bacterial growth inhibition zone (25.0 ± 2.4 mm) was observed in methanolbased leaf extracts against Staphylococcus aureus and maximum fungal growth inhibition zone (22.0 ± 2.1 mm) was observed in Fusarium Oxysporum in methanol based root extracts. In NaCl stressed callus extracts both antibacterial and antifungal activities were observed but the results were not comparable to extracts of in vivo plant based leaf.
Phytochemical screening, Antimicrobial activity, Callus extracts, Rauwolfia serpentina.
Applications and future prospects of proteases: An Overview
Proteases are enzymes with highly specialized proteolytic functions. Proteases are classified as highly demanded enzymes with numerous plant, animal, and microbial sources. They are present in all living things and are crucial for the development and differentiation of cells. They not only have several physiological functions and roles in living beings but are also of great importance in various industries as well thus providing a lot of economic benefits. This review aims to study and analyze the updated information on various biological aspects of proteases highlighting their sources, types, and mode of action on microbial production of the enzyme and their industrial applications.
Pharmaceutical applications, Pathogenic, Protease.
Unusual incidental finding of radiopaque foreign bodies in the entire large colon
We present the case of a 56-year-old female who presented with generalized abdominal discomfort and constipation for 5 days. An abdominal X-ray revealed multiple radiopaque foreign bodies distributed throughout the large colon. The patient denied involvement in any unusual or illegal activities and had no signs of obstruction, infection, or acute distress. Conservative management was initiated, with follow-up imaging planned, but the patient was lost to follow-up. Radiographic findings showed smooth, well-circumscribed foreign bodies measuring 2-3 cm, without a surrounding air-rim or “rosette-sign.” This case emphasizes the need for careful consideration of incidental findings, open communication with patients, and the importance of ethical, nonjudgmental care in addressing such cases
Scientometric, Brain Death, RGR, Time series analysis, highly cited paper, RCI.
Global level research output in brain death: a Scientometric analysis
The present study has analysed nearly the growth of research publications published during the study period from 2012 to 2021 with a sample of 5614 articles published in the field of brain death. The highest number of articles i.e. 652(11.61%) was published in the year 2020. Followed by the second-highest number of articles in 603(10.74%) were contributed in the year 2018. The RGR of an article has gradually decreased from 0.73 in the year 2013 to 0.10 in the year 2021 for the given study period. The doubling time of the publication of articles gradually increases from 0.94 in the year 2013 to 6.66 in the year 2021. The most prolific authors in the field of brain death, it is observed that Lewis, A. has contributed the highest number of articles i.e. 58(15. 43%) research publications in the United States. The large majority of the research output is available in the form of Article 3550(63.23%) research publication, and the country of United States contributed the highest number of articles which amounts to more than 1767(40.43%) of the total publication. The Institutions of with Harvard Medical School alone published 101(14.55%) articles, and the journals of found that Transplantation Proceedings is on the top of the list with the publication of 346(29.88%) publications securing the first rank. The time series analysis statistical application will be expected in the brain death research publications in the year 2025 is around equal to 1661 and in the year 2030 is around equal to 2211. So that time serious analysis confirmed that the publications on the brain death research are increasing trend. The highly cited paper Mallon D.H.; et.al (2023) Defining delayed graft function after renal transplantation: Simplest is best, Transplantation, 96 (10): 885-889. The citation of 219 and document type of article.
The effect of cardiac rehabilitation on exercise tolerance and quality of life in patients with coronary artery bypass grafting (Cabg) in outpatient phase
CABG is most common type of heart surgery. Cardiac Rehabilitation following CABG surgery aims to minimize post- operative pulmonary complications. Quality of life (QOL) and exercise tolerance are important factor in the prognosis of CABG as well as to evaluate effects of different interventions in cardiovascular diseases. 30 samples of both male and female between ages 50 to 80 years who fulfil inclusion criteria were selected randomly for this study. All subjects were undergone Pre and Post 6MWT & evaluated with Pre and Post QOL SF-12 Patient Questionnaire to evaluate the effect of CR Post CABG on Exercise tolerance and QOL. The data was evaluated by statistical analysis which showed there is a significant improvement in exercise tolerance as well as QOL in Patient with CABG after Applying Cardiac rehabilitation exercises.
Cardiac Rehabilitation (CR), Quality of life (QOL), Coronary artery bypass grafting (CABG), 6 Minutes’ walk test (6MWT).
The medicinal wonders and formulation of bael (aegle marmelos): a comprehensive review
Bael, belonging to the Rutaceae family, has long been held in high esteem because of its incredible medicinal properties and wide applications in therapy. With over 80% of the plant species forming angiosperms, they have huge medicinal values; bael remains one of the best examples of such species. Aegle marmelos, classified under the family Rutaceae, or bael tree, has been traditionally used in Ayurvedic medicine and has gained much attention regarding the various sets of bioactive compounds and phytochemicals endowed with a wide range of health benefits - anti-diabetic, anti-microbial, anti-cancerous, and wound healing. This ancient medicinal herb has emerged as the most widely applied in the world where various portions of the bael plant, such as fruit leaves, bark, and seeds are processed into numerous functional products including powders, toffees, candies, jams, and juices.
Bael, Phytochemicals Medicinal Importance, Biological Description, botanical garden, Development of Functional Products, Aegle marmelos.
A comprehensive review: exploring the anti-arthritic anti-inflammatory potential of Annona squamosa (custard apple) leaves
Annona squamosa, also known as custard apple, has many medicinal properties. The use of Annona squamosa is highly recommended to remove toxins from the human body. It is also used to treat respiratory problems such as asthma, allergies, cough prevention and seasonal colds. Research on Annona squamosa has also shown the anti-inflammatory, anti-asthmatic, antimicrobial and anaphylactic, analgesic, anti-diarrheal and immunomodulatory properties of this plant. Annona squamosa from the Annonaceae family is the best example. Many trees and fruits. The fruits are known as custard apples and are edible. The pulp can be used for a flavoring in ice cream. Between 50 and 80% of the fruit is edible. The content of vitamin C is important (35-42 mg/100 g) and slightly more than grapes. The nutritional value of thiamine, potassium and dietary fiber is also important. It is said to contain various substances such as alkaloids, hydroxyl isomeric ketones from the leaves, stegenin, samacquasin, anonasin and anonastatin from the seeds, stegogenin, squamone from the bark. Many studies have reported that it is antibacterial, antidiabetic, antitumor, antimalarial, anthelmintic, antigenotoxic and hepatoprotective. The leaves are used medicinally to treat cancerous tumors, as well as boils, insect bites and other skin ailments. Crushed leaves are smelled to relieve restlessness and fatigue, and are applied to wounds and ailments.
Antibacterial, Antidiabetic, Antitumor, Anti-malarial, Anthelmintic, Anti-genotoxic, Ayurvedic.
Global Level Research Output in Monkey Pox: A Scientometric Analysis
The current study examined the growth of research publications released between 2062 and 2024 using a sample of 203 articles published in the field of Monkey Pox. The biggest number of papers, 121 (59.61%), were published in 2021-2024. During the study period, an article's RGR gradually declined from 0.86 in 1970-1973 to 0.76 in 2021-2024. The doubling time of article publishing gradually increases, from 0.80 in 1970-1973 to 90 in 2021-2024. The most prolific authors in the subject of Monkey Pox, it is found that Marennikova, S.S. has contributed the maximum number of articles i.e., 16 (23.88%) research publications in India. The vast majority of research output is available in the form of Article 121 (59.61%) research publications, and the country- wise distribution of publications shows that India provided the most articles (146), accounting for more than 44 (30.14%) research publications. The institutions with the University of Organisation Mondiale de la Santé published 7 (17.07%) articles, and the journals revealed that Bulletin of the World Health Organization ranked best with 9 (20.45%) publications. The time series analysis statistical application in Monkey Pox research articles is predicted to reach approximately 60 in 2025 and 70 in 2030. So, at the time, rigorous examination confirmed that the number of publications on monkey pox study was increasing. The widely referenced paper is Galdiero S., Falanga A., et al. (2011) Silver nanoparticles as potential antiviral drugs, Molecules, 16(10):8894-8918. The citation count is 778, as is the review's document type.
Scientometric, Tuberculosis, RGR, Time series analysis, Highly cited paper, RCI.
Copyright (c) 2023 International journal of therapeutic innovation
A Review of Bacillus Species Alkaline Protease Production and Industrial Applications
Protein peptide linkages can be hydrolyzed by protease enzymes. They are present in every living thing. Because they are essential to many biological processes and the life cycle of many diseases, bacterial proteases are important medicinal ingredients. Enzyme delivery methods and new technology for rationally engineering proteases will considerably enhance the potential therapeutic applications of enzymes. Proteases are widely used agents in several pharmaceutical business industries. Proteases are present in every living thing. Because of their role in the life cycle of different pathogenic organisms, they could be targeted for the development of therapeutic drugs to treat serious illnesses such as AIDS, cancer, malaria, and bacterial infections. The uses of microbial proteases, including xiaflex, L-asparaginase, L-glutaminase, serrapeptase, serrazime, and L-asparaginase, are the primary emphasis of this review. These enzymes are being utilized to treat cancer, respiratory illnesses, cardiovascular disease, and inflammation. In microbial fermentations, Bacillus species remain the predominant bacterial workhorses. The primary microorganism involved in fermentation is Bacillus subtilis, or natto. Certain Bacillus species are included in the Food and Drug Administration's GRAS (generally regarded as safe) list. Some of the most significant commercial enzyme manufacturers are Bacillus strains that can synthesize and secrete high amounts of extracellular enzymes (20–25 g/L). To summarize the medicinal uses of Basillus protease enzymes in the biological sciences, this paper will discuss the biotechnological features of these enzymes.
Bacterial proteases, pharmaceutical applications, pathogenic, Protease.
Impact of Aerobic Activity on Reaction Time in School-Going Children: A Randomized Controlled Trial
To determine whether reaction time (RT) was immediately influenced by aerobic activity in the form of running in school- aged children. 208 participants, aged 6–12 years, were included in the study after excluding missed follow-up participants which was documented as 6 participants. They were divided into 2 groups, namely the experimental (n=102) and the control group (n=106) using the block randomization method. Afterward, the RT was determined through visual stimuli, via a ruler drop test (RDT). The participants from the experimental group underwent a 20-meter shuttle run test (20-m SRT) whereas the participants of the control group were assigned no task. Each participant's total RDT duration was documented before, immediately following and after 30 seconds of intervention.The obtained results show that there was a statistically significant difference in the value of the RT of children who performed the 20-meter shuttle run test and those who were sitting (p=<0.001 for both groups), While there was no statistically significant difference in RT between children in the two groups for comparisons between prior to and immediately after the intervention (mean= 0.25±0.49 and p=0.30), soon after the intervention and after 30 seconds (mean= 0.28±0.43 and p=0.46), and between before and right soon after 30 seconds of the intervention (mean= 0.53±0.46 and p=0.10), respectively keeping <0.05 as statistically significant. According to the findings of the current investigation, there was no discernible immediate distinction between the RT of individuals who underwent a 20-meter shuttle run test and those who were at rest throughout the intervention period.
Child; Follow-Up studies; Humans; Running.
Nature Nano-Worriers: Phytoconstituents Loaded Lipid Nano Particles against Cancer
This review explores the potential of nanotechnology and phytomedicine in the fight against cancer. It explores the challenges posed by cancer treatment and the potential of using lipid nanoparticles for drug delivery. This article discusses the advantages of using phytochemicals as anti-inflammatory drugs and highlights the role of nanocarriers in improving their bioavailability and therapeutic effects. Different types of lipid-based nanoparticles, such as liposomes, solid lipid nanoparticles, and nanostructured lipid carriers, have been studied for their ability to trigger a response in cancer cells. This review also discusses the challenges and future directions in the field and highlights the need for further research and development to exploit the full potential of lipid nanoparticles loaded with botanical ingredients in cancer therapy
Nanotechnology, Nanomaterials, Lipid-based nanoparticles, Liposome, Solid lipid nanoparticles, Nanostructured lipid carriers, Niosome, Phytoconstituents, Phytomedicine.
Exploring the Protective Potential: A Review of Antioxidant Properties in Banana Peels
<!-- [if gte vml 1]><o:wrapblock><v:shape id="Graphic_x0020_10" o:spid="_x0000_s1026" style='position:absolute;left:0;text-align:left;margin-left:34.55pt; margin-top:156.5pt;width:526.3pt;height:.5pt;z-index:-15727616;visibility:visible; mso-wrap-style:square;mso-wrap-distance-left:0;mso-wrap-distance-top:0; mso-wrap-distance-right:0;mso-wrap-distance-bottom:0; mso-position-horizontal:absolute;mso-position-horizontal-relative:page; mso-position-vertical:absolute;mso-position-vertical-relative:text; v-text-anchor:top' coordsize="6684009,6350" o:gfxdata="[binary] " path="m6684009,l,,,6096r6684009,l6684009,xe" fillcolor="black" stroked="f"> <v:path arrowok="t"/> <w:wrap type="topAndBottom" anchorx="page"/> </v:shape><![endif]--> In recent years, the interest of researchers in agricultural waste has increased, and instead of being ignored, the waste has become attractive to study and benefit from. Banana peels have attracted the attention of researchers due to their bioactive chemical components, and this review article focuses on the antioxidant and antimicrobial activity of banana peels, which can be used as good sources of natural antioxidants and for pharmaceutical purposes in the treatment of various diseases. Banana is an edible fruit of the Musa family (Musaceae) cultivated in tropical and subtropical regions. Banana peel is used as supplementary feed for livestock in their agricultural areas. Its massive by-products are an excellent source of valuable raw materials for other industries by recycling agricultural waste. The aim is to use banana by-products in various food and non-food products and as sources of natural bioactive compounds. It can be concluded that banana peel can be successfully used in food, medicine and other fields. Therefore, banana residues can provide new avenues and research areas for the future.
Antioxidant or Antimicrobial Activity, Chemical Composition of Banana Peels, Nutritional value Banana Peels.
Metal Oxide Nanoparticles in Antifungal Application
<!-- [if gte vml 1]><o:wrapblock><v:shape id="Graphic_x0020_11" o:spid="_x0000_s1026" style='position:absolute;left:0; text-align:left;margin-left:34.55pt;margin-top:139.2pt;width:526.3pt; height:.5pt;z-index:-15727616;visibility:visible;mso-wrap-style:square; mso-wrap-distance-left:0;mso-wrap-distance-top:0;mso-wrap-distance-right:0; mso-wrap-distance-bottom:0;mso-position-horizontal:absolute; mso-position-horizontal-relative:page;mso-position-vertical:absolute; mso-position-vertical-relative:text;v-text-anchor:top' coordsize="6684009,6350" o:gfxdata="[binary] " path="m6684009,l,,,6096r6684009,l6684009,xe" fillcolor="black" stroked="f"> <v:path arrowok="t"/> <w:wrap type="topAndBottom" anchorx="page"/> </v:shape><![endif]--> The increasing incidence of fungal infections, coupled with the rise of antifungal resistance, necessitates the exploration of novel antifungal agents. Metal oxide nanoparticles (MONPs) have emerged as promising candidates due to their unique properties, including high surface area, reactivity, and antimicrobial activity. This review aims to provide an overview of the synthesis, characterization, and antifungal mechanisms of various MONPs, including zinc oxide (Zn O), titanium dioxide (Ti O₂), and copper oxide (Cu O). The effectiveness of these nanoparticles against various fungal pathogens, as well as their potential applications in clinical settings, will be discussed. Additionally, the review addresses safety concerns and environmental implications of using MONPs in antifungal therapies. By highlighting the advancements in this field, this review seeks to encourage further research into the application of MONPs as effective antifungal agents.
Metal oxide nanoparticles, Antifungal activity, Zinc oxide, Titanium dioxide, Copper oxide, Nanotechnology, antifungal resistance.
Copyright (c) 2024 International journal of therapeutic innovation
Cardiovascular Imaging: Recent Advances in Atherosclerosis Diagnosis
<!-- [if gte vml 1]><o:wrapblock><v:shape id="Graphic_x0020_10" o:spid="_x0000_s1026" style='position:absolute;left:0; text-align:left;margin-left:34.55pt;margin-top:87.45pt;width:526.3pt; height:.5pt;z-index:-15727616;visibility:visible;mso-wrap-style:square; mso-wrap-distance-left:0;mso-wrap-distance-top:0;mso-wrap-distance-right:0; mso-wrap-distance-bottom:0;mso-position-horizontal:absolute; mso-position-horizontal-relative:page;mso-position-vertical:absolute; mso-position-vertical-relative:text;v-text-anchor:top' coordsize="6684009,6350" o:gfxdata="[binary] " path="m6684009,l,,,6096r6684009,l6684009,xe" fillcolor="black" stroked="f"> <v:path arrowok="t"/> <w:wrap type="topAndBottom" anchorx="page"/> </v:shape><![endif]--> Recent advancements in cardiovascular imaging have significantly enhanced the diagnosis and management of atherosclerosis, a leading cause of cardiovascular disease. Techniques such as coronary computed tomography angiography (CCTA), magnetic resonance imaging (MRI), and positron emission tomography (PET) have improved our ability to detect and quantify atherosclerotic plaques, assess their stability, and predict adverse cardiovascular events. This review explores the latest developments in imaging modalities, their clinical applications, and the implications for personalized patient care.
Atherosclerosis, Cardiovascular Imaging, Coronary Computed Tomography Angiography, Magnetic Resonance Imaging, Positron Emission Tomography.