Assessment of anticancer potential in Caesalpinia Bondoc: a comparison between leaf and kernel extracts
Doi: https://doi.org/10.55522/ijti.v4i1.0115
Keywords:
- Caesalpinia bonduc, Soxhlet extraction, Ethyl acetate, MTT assay, Anticancer activity, MCF-7 cells, Breast cancer, Bioactive compounds, Cytotoxicity, Natural products, Traditional medicine, Plant-based therapies, Cell viability, Cancer treatment.
Abstract
This study presents a comparative evaluation of the anticancer activity of leaf and seed extracts of Caesalpinia bonduc. Ethyl acetate extracts were prepared using the Soxhlet extraction technique to isolate the plant’s bioactive constituents. C. bonduc was selected due to its long history in traditional medicine and its reported pharmacological potential. The cytotoxic effects of the extracts were assessed against MCF-7 breast cancer cells, a widely used cell line in breast cancer research.The experimental results indicate that both leaf and seed extracts possess notable anticancer properties, demonstrated by their ability to reduce cell viability and inhibit the proliferation of MCF-7 cells. These findings suggest that C. bonduc contains potent bioactive compounds capable of inducing growth inhibition or cell death in cancer cells. Further investigation into the specific phytochemicals responsible for these effects and their underlying mechanisms may support the development of novel plant-based anticancer agents. Overall, this study adds to the growing body of evidence supporting the value of medicinal plants in cancer research and highlights the significance of traditional knowledge in guiding modern therapeutic discoveries.
